H2N2V1, France, Analysis, bibRecord, 000043

Genetic evolution of equine influenza virus strains (H3N8) isolated in France from 1967 to 2015 and the implications of several potential pathogenic factors

Identifieur interne : 000043 ( France/Analysis ); précédent : 000042; suivant : 000044

Genetic evolution of equine influenza virus strains (H3N8) isolated in France from 1967 to 2015 and the implications of several potential pathogenic factors

Auteurs : Stéphanie Fougerolle [France] ; Loïc Legrand [France] ; Fanny Lecouturier [France] ; Corinne Sailleau [France] ; Romain Paillot [Royaume-Uni] ; Aymeric Hans [France] ; Stéphane Pronost [France]

Source :

Virology [ 0042-6822 ] ; 2017-05.

RBID : Hal:hal-02168198

Abstract

Equine influenza virus (EIV) is a major respiratory pathogen of horses despite the availability of equine influenza vaccines. This study aimed to determine genetic evolution of EIV strains in France between 1967 to present. A whole genome comparative analysis was also conducted on recent French strains in order to identify potential factors of pathogenicity. Comparison of French EIV sequences with vaccine and worldwide epidemic strains revealed amino acid substitutions in both haemagglutinin (HA) and neuraminidase, especially within the antigenic sites and/or close to receptor binding sites (HA). Amino acid substitutions were also identified in other genes, mainly the polymerase complex proteins and PB1-F2. Viruses belonging to Eurasian and American lineages have circulated until 2003 and Florida sub-lineage Clade 2 strains predominates since 2005. The last French strain (2015) displayed several specificities in HA suggesting the occurrence of antigenic drift with presence of pathogenic markers in the PA and PB1-F2 genes.

Url:

https://hal-normandie-univ.archives-ouvertes.fr/hal-02168198

DOI: 10.1016/j.virol.2017.02.003

Affiliations:

France, Royaume-Uni

Links toward previous steps (curation, corpus...)

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to stream Main, to step Curation: 000247
to stream Main, to step Exploration: 000247
to stream France, to step Extraction: 000043

Links to Exploration step

Hal:hal-02168198

Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>Equine influenza virus (EIV) is a major respiratory pathogen of horses despite the availability of equine influenza vaccines. This study aimed to determine genetic evolution of EIV strains in France between 1967 to present. A whole genome comparative analysis was also conducted on recent French strains in order to identify potential factors of pathogenicity. Comparison of French EIV sequences with vaccine and worldwide epidemic strains revealed amino acid substitutions in both haemagglutinin (HA) and neuraminidase, especially within the antigenic sites and/or close to receptor binding sites (HA). Amino acid substitutions were also identified in other genes, mainly the polymerase complex proteins and PB1-F2. Viruses belonging to Eurasian and American lineages have circulated until 2003 and Florida sub-lineage Clade 2 strains predominates since 2005. The last French strain (2015) displayed several specificities in HA suggesting the occurrence of antigenic drift with presence of pathogenic markers in the PA and PB1-F2 genes.</p>
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   |type=    RBID
   |clé=     Hal:hal-02168198
   |texte=   Genetic evolution of equine influenza virus strains (H3N8) isolated in France from 1967 to 2015 and the implications of several potential pathogenic factors
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	Serveur d'exploration H2N2
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Serveur d'exploration H2N2

Genetic evolution of equine influenza virus strains (H3N8) isolated in France from 1967 to 2015 and the implications of several potential pathogenic factors

Genetic evolution of equine influenza virus strains (H3N8) isolated in France from 1967 to 2015 and the implications of several potential pathogenic factors

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